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KMID : 1025520130550060515
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Journal of Animal Science and Technology
2013 Volume.55 No. 6 p.515 ~ p.520
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Association of a Pyruvate Kinase M2 (PKM2) Polymorphism with Back Fat Thickness in Berkshire Pigs
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Cho Eun-Seok
Jeon Hyeon-Jeong
Lee Si-Woo
Park Jong-Woon
Raveendar Sebastian
Jang Gul-Won
Kim Tae-Hun
Lee Kyung-Tai
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Abstract
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Pyruvate kinase M2 (PKM2) is a key regulatory enzyme in the glycolytic pathway. It is one of four pyruvate kinase isoenzymes that widely differ in their occurrence according to tissue type. PKM2 is expressed in differentiated tissues, such as fat tissues, lung, as well as normal proliferating cells, embryonic cells, and tumor cells. The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in the PKM2 gene with meat quality traits in Berkshire pigs. We detected a SNP (g.34341 A>G) in the 3'UTR region of the PKM2 gene in 670 Berkshire pigs through DNA sequencing. Three genotypes, AA, AG, and GG, were found for this SNP, but based on an association analysis with meat quality traits, genotype AA was significantly associated with thicker back fat than genotype GG (p=0.027). Therefore, the g.34341 A>G polymorphism in the 3'UTR region of the porcine PKM2 gene could be applied in pig breeding programs to improve back fat thickness.
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KEYWORD
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Meat quality, Pyruvate Kinase M2, Pig, Single nucleotide polymorphism
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